Polyomavirus Nephropathy
نویسندگان
چکیده
منابع مشابه
Polyomavirus Nephropathy: Quantitative Urinary Polyomavirus-Haufen Testing Accurately Predicts the Degree of Intrarenal Viral Disease
BACKGROUND A qualitative highly predictive urinary test for polyomavirus nephropathy (PVN) is the PV-Haufen test. This article evaluates whether a quantitative PV-Haufen analysis, that is, the number of PV-Haufen shed per milliliter urine, predicts PVN disease grades and the severity of intrarenal PV replication. METHODS Polyomavirus-Haufen were counted in 40 urine samples from patients with ...
متن کاملPolyomavirus associated nephropathy after kidney and pancreas transplantation: case report.
Polyomavirus virus associated nephropathy (PVAN) is an important cause of graft failure in the renal transplant population. The prevalence of PVAN has increased from 1% to 10% in the past decade, leading to loss of transplanted organ in 30% to 80% of cases. In the absence of specific antiviral drugs, early detection of disease and modification/reduction of immunosuppressive regimen is currently...
متن کاملAntiviral therapy for polyomavirus-associated nephropathy after renal transplantation.
Polyomavirus-associated nephropathy (PVAN) has recently emerged as an important cause of allograft failure following renal transplantation. The BK virus is the most important polyomavirus associated with this condition. The mainstay of therapy for PVAN is a prompt immunosuppressive dose reduction in conjunction with careful monitoring for BK viraemia. A number of antiviral agents have been trie...
متن کاملPolyomavirus nephropathy: a current perspective and clinical considerations.
During the last decade, the human polyomaviruses (BK virus and, much less commonly, JC virus) have entered the realm of routine clinical decision making for providers caring for kidney transplant recipients. The emergence of polyomavirus-associated nephropathy (PVAN) as an important clinical entity coincided with the development and use of more potent immunosuppression agents, currently the onl...
متن کاملPolyomavirus BK Nephropathy-Associated Transcriptomic Signatures: A Critical Reevaluation
Background Recent work using DNA microarrays has suggested that genes related to DNA replication, RNA polymerase assembly, and pathogen recognition receptors can serve as surrogate tissue biomarkers for polyomavirus BK nephropathy (BKPyVN). Methods We have examined this premise by looking for differential regulation of these genes using a different technology platform (RNA-seq) and an indepen...
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ژورنال
عنوان ژورنال: Transplantation
سال: 2015
ISSN: 0041-1337
DOI: 10.1097/tp.0000000000000367